CO-CRYSTAL OF ANTIBODY 11F8 FAB FRAGMENT AND EGFR EXTRACELLULAR DOMAIN AND USES THEREOF

摘要

The present invention relates to co-crystals of antibody 11 F8 Fab fragments and the complete extracellular domain of EGFR or isolated domain III of EGFR, and structural coordinates obtained from such crystals. Such coordinates are useful for identifying mimetics that bind to the extracellular domain of EGFR. Such mimetics may, for example, inhibit binding of ligands to EGFR, inhibit activation of EGFR, and/or reduce proliferation of tumor cells.