发明名称 |
Anti MIF antibodies |
摘要 |
<p>The present application relates to monoclonal antibodies and antigen-binding portions thereof, that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The application also relates to isolated heavy and light chain immunoglobulins derived from the anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present application also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.</p> |
申请公布号 |
AU2008346517(A1) |
申请公布日期 |
2009.07.16 |
申请号 |
AU20080346517 |
申请日期 |
2008.12.30 |
申请人 |
DYAX CORPORATION;BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A. |
发明人 |
MICHAEL THIELE;MANFRED RIEGER;RENE HOET;JUERGEN MUELLBERG;C. GEERT MUDDE;RANDOLF KERSCHBAUMER;FRIEDRICH SCHEIFLINGER |
分类号 |
C07K16/24;A61K39/395;A61P1/00;A61P13/12;A61P35/00;C12N15/13 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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