发明名称 |
A NEW INHIBITOR SCAFFOLD FOR THE INHIBITION OF THE ENZYME PHOSPHOENOLPYRUVATE CARBOXYKINASE |
摘要 |
<p>A method for designing a molecule capable of functioning as a PEPCK inhibitor can include identifying a molecule that has a size capable of fitting into and interacting with the PEPCK binding site and at least one of the following: (a) a first terminal substituent having co-planar atoms acting as metal ligands to the active site metal ion PEPCK; (b) at least one of an atom or substituent at positions 2 or 3 from the first terminal substituent includes a neutral carbon center or include an oxygen, sulfur, selenium, or other atom with similar physiochemical properties; (c) at least one of an atom or substituent at positions 2 or 3 from the first terminal substituent is devoid of an electropositive atom or substituents; or (d) a second terminal substituent opposite of the first terminal substituent, said second terminal substituent having an atom that is a hydrogen boding acceptor and/or is negatively charged. For example, the PEPCK inhibitor can include at least one, two, three, or four of (a), (b), (c), or (d).</p> |
申请公布号 |
WO2009089541(A2) |
申请公布日期 |
2009.07.16 |
申请号 |
WO2009US30761 |
申请日期 |
2009.01.12 |
申请人 |
UNIVERSITY OF KANSAS;FLORIDA MEMORIAL UNIVERSITY;CARLSON, GERALD;HOLYOAK, TODD;SULLIVAN, SARAH;STIFFIN, ROSE, MARY |
发明人 |
CARLSON, GERALD;HOLYOAK, TODD;SULLIVAN, SARAH;STIFFIN, ROSE, MARY |
分类号 |
C07C275/16 |
主分类号 |
C07C275/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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