| 发明名称 |
ANTIBODY DISULFIDE ISOMERS, USE THEREOF, AND METHODS FOR ANALYZING THE SAME |
| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide methods for detecting disulfide isomers of antibodies. <P>SOLUTION: The qualitative and quantitative analyses for antibody fragment disulfide isomers comprise: a step (a) wherein antibody fragments are pre-treated with an organic solvent; a step (b) wherein the pre-treated antibody fragments are digested with protease in the presence of the organic solvent; and a means (c) wherein the fragments digested with protease are resolved. <P>COPYRIGHT: (C)2009,JPO&INPIT</p> |
| 申请公布号 |
JP2009153528(A) |
申请公布日期 |
2009.07.16 |
| 申请号 |
JP20090099513 |
申请日期 |
2009.04.16 |
| 申请人 |
PHARMACIA CORP |
发明人 |
MOZIER NED M;DUFIELD ROBERT L;MO JIANMING;BILD GARY S |
| 分类号 |
C12Q1/37;C07K16/24;C12P21/08 |
主分类号 |
C12Q1/37 |
| 代理机构 |
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| 地址 |
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