| 摘要 |
To provide a novel process for producing an optically active allyl compound which is useful as an intermediate raw material for e.g. pharmaceutical products. A process for producing an optically active allyl compound of the formula (4): (wherein "*" represents an asymmetric carbon atom), which comprises reacting an allyloxy compound of the formula (1): (wherein R1 is a C1-6 alkyl group or a C1-6 alkoxyl group, and each of R2, R3, R4, R5 and R6 independently is a C1-6 alkyl group which may be linear, branched or cyclic, a hydrogen atom or a C6-12 aromatic group, provided that R2 and R6 may be located in the same ring) with a hydrogenated compound of the formula (3): (wherein X is a carbon atom, an oxygen atom, a sulfur atom or a nitrogen atom, and each of R8, R9 and R10 independently is a C1-24 alkyl group which may be linear, branched or cyclic, a C1-24 alkylcarbonyl group which may be branched or cyclic, a C1-24 alkoxycarbonyl group which may be branched or cyclic, a hydrogen atom, a halogen atom or a C6-10 aromatic group, or two of R8, R9 and R10 may together form a ring containing one or two carbonyl groups), in the presence of a palladium compound and an optically active phosphine ligand of the formula (2): (wherein each of Ar1, Ar2, Ar3 and Ar4 independently is a C6-10 aromatic group, and R7 is a structure having at least one asymmetric center or axial chirality), wherein a tertiary amine of the formula (5): (wherein each of R11, R12 and R13 independently is a C2-12 aliphatic group or a C2-12 substituted aliphatic group, which may be linear, branched or cyclic, or a C6-10 aromatic group or a C6-10 substituted aromatic group) is present in the above reaction system.
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