GENETICALLY-MODIFIED CELL LINE FOR PRODUCING CLONED MINIATURE PIGS FOR XENOTRANSPLANTATION AND METHOD FOR PREPARING THE SAME.

摘要

The present invention relates to a targeting vector specific for a xenoantigen determining antigen synthesizing gene capable of knock-outing the xenoantigen determining antigen synthesizing gene using homologous recombination technologies and integrating human complement inhibiting gene and/or human CD39 gene at the loci of the xenoantigen determining antigen synthesizing gene.