PREVENTION OF PLAQUE FORMATION

摘要

A compound having the formula (I) or a salt thereof in the manufacture of a medicament for the removal or prevention of plaque formation, wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, the sum of the carbon atoms in the groups R1 and R2 being at least 10 and preferably 10 to 20, wherein the medicament further comprises a bacterial adhesin peptide or an antibody that binds to a bacterial adhesin peptide.