| 摘要 |
A compound activating a peroxisom proliferator-activated receptor (PPAR)-alpha and gamma is provided to use as a therapeutic agent which has blood pressure reducing effect and bioavailability with less side effect. A peroxisom proliferator-activated receptor (PPAR) agonist for preventing and treating diabetes comprises a compound of the chemical formula I, its racemic mixture, optical isomer or partial isomer or it pharmacologically allowable salt. In the chemical formula I, R1 is hydrogen, linear or branch C1-6 alkyl, R2 and R3 is hydrogen, linear or branch C1-6 alkyl, C1-6 alkoxy, A1, A2, and A3 is separately carbon, nitrogen, oxygen or sulfur atom, R4 is hydrogen, linear or branch C1-6 alkyl, linear or branch C2-6 alkenyl.
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