| 摘要 |
We want to use the product Dermatix or some equivalent product to 1) try to proliferate stem cells and 2) use it for scarred tissue inside the body a procedure done befo re grafting or adding or scaffolding stem cells (eg. into a spinal chord injury patient) so the stem cells aren't blocked from taking to injured wound. Taken from Dermatix website: The Innovation Dermatix.TM. Gel is a patented proprietary formula containing bio-inert and biocompatible silicone compounds, namely polysiloxane, silicon dioxide and nonvolatile silicone components. It uses basic long-chain polymers as topical silicone-gel sheeting. The result is a waterproof, gas-permeable membrane that acts like an extra layer of skin. It helps to soften and flatten the scar and to reduce pain, itching and scar-associated discoloration, while maintaining the moisture balance and elasticity of the adjacent skin. We are looking at running electrode through stem cell colonies to deliver electrical impulses to the stem cells in the hope of continuing the stem cells proliferation. We also plan to use Netrin-1 protein 1) harness and study its effects to facilitate the stem cells to repair itself to and use to cause stem cells to proliferate 2) and cause the stem cells to convert into axons for spinal chord and brain injuries3) we could also us e it in conjunction stem cell injections. Other Topical Ointments include: Retin-A (tretinoin) perhaps in combination with hydroquinone and cortisone cream and as well alpha hydroxy acids and vitamin C serums and possibly steroids such as triamcinolone. We are using Helix Aspera Muller Glycoconjugates snail/slug slime to enhance proliferation of stem cells. It is comprised complex sugar molecules bound to proteins, peptides, enzymes, coenzymes, oligoelements that play a role in messengers's communication between cells moderators of inflammatory reaction when skin if damaged, and regulators of fiberoblast proliferation and functions of the skin matrix and new connectiv e tissues such as collagen and elastin fibers and water holding molecules (glycosaminoglycans and proteoglycans. The Below is Taken BioSkincare Website: FACTORS THAT HELP TO RECOVER THE NORMAL PHYSIOLOGY OF THE SKIN. ~ Low molecular weight proteins that activate Fibroblast Growth Factor activity. Fibroblast proliferation is key for they are the stem cells in the basal membrane of the skin that give rise to new connective tissues: collagen and elastin fibers plus the glycosaminoglycans and proteoglycans that act as the glue that bind cells together and as fillers with a large capacity to withho ld many times their weight in water and give skin strenght, elasticity and the capcity to withstand overstretching without breaking of skin fibers. ~ High molecular weight proteins that work as Oxygen carriers (copper- haemocyanin) ~ Copper peptides that induce the degradation of "extra-large" collagen aggregates found in scar tissues such as those in stretch marks, and promotes the synthesis of smaller more regular collagen as is normal skin ~ Enzymes, both with Collagenase and Gelatinase activities that degrade damaged proteins and scar tissues ~ Hyaluronic Acid, provides deep tissue hydration ~ Glycoproteins / mucopolysaccharides that act as signaling molecules and enhance communication among and within cells, thus coordinating an orchestrated process that recognizes damaged and scar tissues, and activates the enzymes that "digest" or further degrade them into their amino - acid and other components, and uses those same components for the reconstruction of the extracellular matrix ~ Trace elements (Copper, Zinc, Iron, Calcium), some acting as coenzymes, necessary for Cellular Renewal, ~ Low molecular weight antioxidant compounds with Antioxidant & Anti- inflammatory effects. To remove the scarring tissue from getting out of the way for the stem cells to bond to the healthy unscarred spinal cordtissue, in addition to substances such as Dermatix, we plan to try surgical procedures such as Dermabrasion (30% GP) and Chemica l Peel (10%). We also plan to use it in conjunction with (prior to) injecting stem cells into scarred injury (eg. scarred tissue) anywhere where there is scarred tissue. After removing the scarring, and adding stem cells to the injured area of th e spinal chord, we use netrein-1 then we apply electrodes to prime the stem cells to grow into stem cells. Additionally we could use detectors for faint muscle signals (initially with robotic help the limb's movement) then as the signal gets stronger, by retrains the brain signalling (neuron sounds or other form or mental activity detector) we could add neuron muscle patches that strengthens the muscle and eventually turn down the strength of the nerve patch signal and teach the patient to concentrate to increase the brains and nerve signals th at operate the limb movement manually. Furthermore, we will treat the stem cells with retinoic acid and vitamin
|
