发明名称 |
HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE |
摘要 |
<p>Compounds of formula (I), and salts, N-oxides, hydrates and solvates thereof are histone deacetylase inhibitors and are useful in the treatment of cell proliferative diseases, including cancers: wherein Q, V and W independently represent—N═or—C═; B is a divalent radical selected from (B1), (B2), (B3), (B4), (B5) and (B6). wherein the bond marked * is linked to the ring containing Q, V and W through -[Linker1]- and the bond marked ** is linked to A through -[Linker2]-; A is an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system; -[Linker1]- and -[Linker2]- independently represent a bond, or a divalent linker radical; and R is (a) a radical of formula R1R2CHNH—Y-L1-X1—(CH2)z—or (b) a radical of formula R-L1-Y1—(CH2)z—.</p> |
申请公布号 |
EP2077999(A1) |
申请公布日期 |
2009.07.15 |
申请号 |
EP20060794937 |
申请日期 |
2006.10.30 |
申请人 |
CHROMA THERAPEUTICS LIMITED |
发明人 |
MOFFAT, DAVID FESTUS CHARLES;DAY, FRANCESCA ANN;PATEL, SANJAY RATILAL;BELFIELD, ANDREW JAMES;DONALD, ALISTAIR DAVID GRAHAM;DAVIDSON, ALAN HORNSBY;DRUMMOND, ALAN HASTINGS |
分类号 |
C07D239/42;A61K31/506;A61P7/12;A61P9/00;A61P19/02;A61P25/28;A61P29/00 |
主分类号 |
C07D239/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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