| 摘要 |
A transdermal therapeutic system (TTS), comprising a backing layer, an adhesive matrix containing fentanyl (I) as active agent and a removable protective layer, has a penetration accelerator-free adhesive matrix of: (a) basic acrylate copolymer (preferably containing hydroxyethyl acrylate units) crosslinked with an organotitanium compound; or (b) non-crosslinked basic acrylate copolymer containing hydroxyethyl acrylate and vinyl acetate units. |
