发明名称 |
G-CSF KONJUGATE |
摘要 |
The invention relates to polypeptide conjugates comprising a polypeptide exhibiting G-CSF activity and having an amino acid sequence that differs from the amino acid sequence of human G-CSF in at least one specified introduced and/or removed amino acid residue comprising an attachment group for a non-polypeptide moiety, and having at least one non-polypeptide moiety attached to an attachment group of the polypeptide. The attachment group may e.g. be a lysine, cysteine, aspartic acid or glutamic acid residue or a glycosylation site, and the non-polypeptide moiety may e.g. be a polymer such as polyethylene glycol or an oligosaccharide. The conjugate has one or more improved properties such as increased biological half-life and reduced side effects. |
申请公布号 |
AT435033(T) |
申请公布日期 |
2009.07.15 |
申请号 |
AT20010900105T |
申请日期 |
2001.01.09 |
申请人 |
MAXYGEN HOLDINGS LTD |
发明人 |
NISSEN, TORBEN LAUESGAARD;ANDERSEN, KIM VILBOUR;HANSEN, CHRISTIAN KARSTEN;MIKKELSEN, JAN MOLLER;SCHAMBYE, HANS THALSGAARD |
分类号 |
A61K47/48;C12N15/09;A61K38/00;A61K47/42;A61P7/00;A61P31/04;A61P31/18;A61P37/04;C07K14/535;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/27;C12P21/02 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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