POSITIVELY CHARGED MEMBRANE

摘要

The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coati ng that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising porous substrate and a crosslinked coating comprising pendent cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration an d purification of biomolecules such as proteins, nucleic acids, endotoxines, and the like.