| 摘要 |
FIELD: chemistry; medicine. ^ SUBSTANCE: in novel spiropentacyclic compounds of formula (I) R1 and R2 collectively with nitrogen atom, to which they are bound, form 6-member monocyclic saturated heterocyclic ring, which can optionally contain 1 additional O or N; R3 represents hydrogen, halogen or lower alkyl; R4 and R5 each independently represents halogen; and X represents -C(O)- or -SO2-; or their pharmaceutically acceptable salts, intended for application as therapeutically active substances for treatiment and/or prevention of diseases connected with modulation of CB1 receptors and also pharmaceutical composition based on said compounds. ^ EFFECT: novel compounds possess useful biological properties. ^ 12 cl, 1 tbl, 6 ex |
