| 摘要 |
N-oxide forms, the pharmaceutically acceptable additive salts and stereochemical isomers of the substance (I) wherein n=1, 2, 3 or 4; Z representsО, S, NR, SO or SO; Ris hydrogen, cyano, hydroxy orСalkyl, optionally substituted by halogen; Ris hydrogen,Сalkyl orСalkyloxy-; Ris hydrogen,Сalkyl,Сalkyloxy-, or Rin combination with R, produce bivalent radical selected from -О-СН- (a), -NR-CH- (b), -(CRR)- (с) and -CR= (d), wherein m = 1 or 2, and each of R, R, Rand Rare independently selected from hydrogen orСalkyl; Ris hydrogen, halogen, hydroxyl, cyano, amino, NRR,Сalkyloxy-, optionally substituted by one or when possible two or three substituents selected from hydroxyl and halogen or RrepresentsСalkyl optionally substituted by one or when possible two or three substituents selected from hydroxyl and halogen; Ris hydrogen, halogen, cyano, amino, phenyl, hydroxyl,Сalkyloxycarbonyl, hydroxycarbonyl, -NRRorСalkyl substituted by one or several substituents selected from hydroxycarbonyl, phenyl,Сalkyloxy-, or NRR; Ris hydrogen; Rand Rindependently represent hydrogen,Сalkyl orСalkylcarbonyl-; Rand Rindependently represent hydrogen,Сalkyl orСalkylcarbonyl-; Rand Rindependently represent hydrogen,Сalkyl orСalkylcarbonyl-; RіRindependently represent hydrogen,Сalkyl orСalkylcarbonyl-.(І) |
