INHIBITEURS D'AGE

摘要

The invention relates to a compound having general formula I, wherein: X represents CH₂, C-O, C-S or CHOH, X represents CH₂, C-O, C-S or CHOH, R₁ represents an amino acid which is optionally substituted by one or more halogen atoms, preferably fluorine, or by one or more CF₃ groups and n=0.1 or 2, or X represents CH₂, C-O, C-S, CHOH, R₁ represents a peptide containing two amino acids, each amino acid being optionally substituted by one or more halogen atoms, preferably fluorine, or by one or more CF₃ groups and n=0 or 1, or XR₁ represent PO₃H or SO₃H and n=0.1 or 2; R₂ represents H, XR₁, an alkyl group at C₁-C₆, an aralkyl group at C₁-C₆ or an aryl group, whereby the alkyl, aralkyl and aryl groups can be substituted by an amine NH₂, a carboxylic group COOH, one or more halogen atoms, preferably fluorine, or one or more CF₃ groups; or the pharmaceutically-acceptable addition salts, isomers, enantiomers and diastereoisomers of said compound, mixtures thereof, and pharmaceutical or cosmetic compositions comprising same and the use thereof as an AGE-inhibitor drug that traps reactive carbonyl compounds.