发明名称 |
METHODS FOR IDENTIFYING COMPOUNDS THAT MODULATE PHB DOMAIN PROTEIN ACTIVITY AND COMPOSITIONS THEREOF |
摘要 |
The invention relates to the finding that PHB domain polypeptides can bind cholesterol and related compounds and are involved in the regulation of various cellular activities. Accordingly, the invention includes methods of identifying compounds that can bind to and/or modulate activity of a PHB domain polypeptide such as Podocin or MEC2.
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申请公布号 |
US2009175845(A1) |
申请公布日期 |
2009.07.09 |
申请号 |
US20060091223 |
申请日期 |
2006.10.24 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
CHALFIE MARTIN;BENZING THOMAS |
分类号 |
A61K31/7088;A61K31/56;A61K39/395;A61P43/00;C07H21/04;C12Q1/68 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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