OPTICALLY ACTIVE 3-AMINOPYRROLIDINE SALT, PROCESS FOR PRODUCTION THEREOF, AND METHOD FOR OPTICAL RESOLUTION OF 3-AMINOPYRROLIDINE

摘要

Disclosed is an optically active 3-aminopyrrolidine (3AP) salt having a high optical purity, which is useful as an intermediate for the industrial production of optically active 3AP. Also disclosed is a process for producing the optically active 3AP salt efficiently. Further disclosed is an effective method for the optical resolution of 3AP on an industrial scale. Racemic 3AP is reacted with optically active 2-methoxyophenylacetic acid in an aqueous solvent in the presence of a mineral acid such as hydrochloric acid to produce a diastereomer salt composed of 1 mole of optically active 3AP and 2 moles of optically active 2-methoxyphenylaceticacid, and the separation of the diastereomer salt is carried out. In this manner, 3AP can be optically resolved efficiently.