发明名称 |
METHODS OF REGULATING EXPRESSION OF GENES OR OF GENE PRODUCTS USING SUBSTITUTED TETRACYCLINE COMPOUNDS |
摘要 |
The present invention relates, at least in part, to the use of substituted tetracycline compounds for regulation of expression of nucleic acids operably linked to a tetracycline operator system. The invention pertains to compounds used in a regulatory system which utilizes components of the Tet repressor/operator/inducer system of prokaryotes to regulate gene expression in cells. Use of certain substituted tetracycline compounds, as featured in the methods of the invention, result in improved dose-response results when compared to those for e.g., tetracycline and doxycycline. Certain methods of the invention thus allow for enhanced control of the Tet repressor/operator/inducer system in regulating gene expression in cells. |
申请公布号 |
WO2007133798(A3) |
申请公布日期 |
2009.07.09 |
申请号 |
WO2007US11700 |
申请日期 |
2007.05.15 |
申请人 |
PARATEK PHARMACEUTICALS, INC.;NELSON, MARK, L.;DRAPER, MICHAEL |
发明人 |
NELSON, MARK, L.;DRAPER, MICHAEL |
分类号 |
C12N15/63 |
主分类号 |
C12N15/63 |
代理机构 |
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