Anti-Alpha V Immunoliposome Composition, Methods, and Uses

摘要

An immunoliposome composition targeted to the alphaV-integrin subunit of integrin receptors comprised of ligand-targeted liposomes bearing at least one targeting-ligand derived from an antibody and having binding specificity for at least one integrin receptor comprising an alpha V subunit including alphavbeta1, alphavbeta3 alphavbeta5, alphavbeta6, or alphavbeta8 integrin cell receptors is described. The antibody-derived targeting ligand may be a Fab' fragment, a scFv, or the like. Binding of the immunoliposome to alphav-integrin expressing cells, preferably results in internalization of the immunoliposome for cytoplasmic delivery of a liposome-entrapped agent.