| 摘要 |
<p>The present invention provides methods for verifying the authenticity of biological samples containing nucleic acid molecules. The methods enable to distinguish between in vitro generated DNA and in vivo generated DNA and can be used in forensics to assure that DNA profiles produced from crime scene samples are genuine. The methods employ an array of nucleic acid based procedures for verifying the authenticity of a DNA sample such as polymerase chain reaction, sodium bisulfite treatment, and methylation-sensitive endonuclease digestion. The invention further provides kits for verifying the authenticity of biological samples containing nucleic acids employing the methods and reagents described in the invention.</p> |
