| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide camptothecin derivatives having antitumor activity. <P>SOLUTION: The camptothecin derivatives represented by formula (1) [wherein, R<SB>1</SB>is selected from: an acyl, a 2-8C alkenyl or a 2-8C alkynyl, optionally substituted by one or more halogen atoms, hydroxy group, a lower alkyloxy group or a lower alkyl group for a corresponding hydrogen atom therein; oxo; arylalkenyl; arylalkynyl; heterocycle; -S(O)-lower alkyl; -lower alkyl-P(O)R<SB>6</SB>R<SB>7</SB>, or X-(1-6C alkylene, 2-8C alkenylene, or 2-8C alkynylene)-SiR<SB>8</SB>R<SB>9</SB>R<SB>10</SB>; R<SB>2</SB>is halo, lower alkyl, amino or nitro; R<SB>11</SB>is hydrogen, hydroxy or acetoxy; and X is sulfur or X represents no substitution], and pharmaceutically acceptable salts thereof are provided. <P>COPYRIGHT: (C)2009,JPO&INPIT</p> |
