发明名称 |
Coagulation Factor X Polypeptides With Modified Activation Properties |
摘要 |
The present invention relates to modified cDNA sequences coding for factor X polypeptides, in particular human factor X and its derivatives which can bypass the need for either factor VIIIa/factor IXa or factor VIIa/tissue factor for activation. The invention relates further to recombinant expression vectors containing such modified cDNA sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having altered activation properties, and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises such modified DNA sequences.
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申请公布号 |
US2009175828(A1) |
申请公布日期 |
2009.07.09 |
申请号 |
US20070224182 |
申请日期 |
2007.02.19 |
申请人 |
SCHULTE STEFAN;HAUSER HANS-PETER;KALINA UWE;WEIMER THOMAS |
发明人 |
SCHULTE STEFAN;HAUSER HANS-PETER;KALINA UWE;WEIMER THOMAS |
分类号 |
A61K38/36;A61P7/02;C07K14/745;C12N5/10;C12N15/12;C12N15/63;C12P21/00 |
主分类号 |
A61K38/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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