发明名称 |
IMPROVED FIBRONECTIN-BASED BINDING MOLECULES AND THEIR USE |
摘要 |
The invention provides fibronectin-based binding molecules and methods for introducing donor CDRs into a fibronectin-based binding scaffold, in particular, Fn3. The fibronectin-based binding molecules of the invention may be further conjugated to another moiety, for example, Fc, anti-FcRn, HSA, anti-HSA, and PEG, for improved half life and stability, particularly in mammalian cells. The invention also provides methods for screening such molecules for binding to a target antigen as well as the manufacture and purification of a candidate binder. |
申请公布号 |
WO2009083804(A2) |
申请公布日期 |
2009.07.09 |
申请号 |
WO2008IB03962 |
申请日期 |
2008.12.22 |
申请人 |
NOVARTIS AG;KOLBINGER, FRANK;VINCENT, KAREN, JANE;BRANNETTI, BARBARA;EWERT, STEFAN |
发明人 |
KOLBINGER, FRANK;VINCENT, KAREN, JANE;BRANNETTI, BARBARA;EWERT, STEFAN |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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