A CAPECITABINE HYDROXYL-DERIVATIVE, ITS PREPARATION PROCESSES AND USES FOR PREPARING CAPECITABINE

摘要

A capecitabine hydroxyl-derivative as the following structure, its preparation processes and intermediates in the processes, and the use of hydrolyzing the said capecitabine hydroxyl-derivative to get capecitabine. The capecitabine hydroxyl-derivative provides the proper protecting group that can be removed by hydrolysis to get capecitabine under a weaker acidic or basic condition. The process of the reaction step is well controlled, the purity of the raw product is high and the resulting capecitabine meets the standard of US pharmacopoeia without complicated purification.