Culturing heterologous protein-secreting mammalian cells, such as CHO or BHK cells, at 35.1 -36.50C and/or at pH 7.15-7.20 and/or at a dissolved CO2 concentration of 10% or lower. Preferred heterologous proteins are Factor VIII, ADAMTS-13, f urin or Factor VII.
申请公布号
WO2009086309(A2)
申请公布日期
2009.07.09
申请号
WO2008US88036
申请日期
2008.12.22
申请人
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE SA;GIOVAGNOLI, ANDRE;ROY, SYLVAIN;DUCROS, VERONIQUE;CHARLOT, VIRGINIE;STAUFFER, YVES-OLIVIER
