| 摘要 |
<p>The present invention relates to a method for preparing a hydroxy-bisphosphonic acid derivative or a salt thereof, from the corresponding carboxylic acid, comprising the following steps: - activation of the carboxylic acid function in the form of the boronate derivative thereof through the action of a borane, then - reaction with tris(trimethyl-silyl)phosphite, under Arbuzov conditions - treatment with an alcohol, chosen in particular from an aliphatic alcohol or trifluoromethanol, and - separation of the hydroxy-bisphosphonic acid derivative formed, from the reaction medium.</p> |
| 申请人 |
UNIVERSITE DE NANTES;CHU NANTES;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);EGOROV, MAXIM;FORTUN, YANNICK;HEYMANN, DOMINIQUE;LEBRETON, JACQUES;MATHE, MONIQUE;PADRINES, MARC;REDINI, FRANCOISE |
发明人 |
EGOROV, MAXIM;FORTUN, YANNICK;HEYMANN, DOMINIQUE;LEBRETON, JACQUES;MATHE, MONIQUE;PADRINES, MARC;REDINI, FRANCOISE |
