SYSTEMS AND METHODS FOR FORMING PATTERNED EXTRACELLULAR MATRIX MATERIALS
摘要
<p>An extracellular matrix (ECM)-based scaffold suitable for artificial skin as well as other structures can be formed using a bioreactor fabricated with a pattern that introduces desired structural features, on the microscale and/or nanoscale, to ECM-precursors gelled in the bioreactor. The bioreactor can produce a finely patterned scaffold - over clinically relevant size scales - sufficiently robust for routine handling. Preformed ECM-based scaffolds can also have microscale and/or nano-scale structural features introduced into a surface thereof. ECM-based scaffolds may be formed with well-defined structural features via microetching and/or remodeling via 'contact degradation.' A surface-activated pattern can be used to degrade the ECM-based scaffold at contact regions between the pattern and the ECM. The produced ECM-based scaffolds can have structures of dimensions conducive to host tissue ingrowth while preserving the fibrous structure and ligand density of natural ECMs.</p>
申请公布号
WO2009086535(A2)
申请公布日期
2009.07.09
申请号
WO2008US88486
申请日期
2008.12.29
申请人
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;CHEUNG, YUK KEE;SIA, SAMUEL, K.;CHIN, CURTIS, D.;GILLETTE, BRIAN, MICHAEL
发明人
CHEUNG, YUK KEE;SIA, SAMUEL, K.;CHIN, CURTIS, D.;GILLETTE, BRIAN, MICHAEL