摘要 |
The present invention relates to a preparation process useful in synthesis of atorvastatin, more particularly a process for preparing atorvastatin is effective in treating hyperlipemia, comprising protecting the dihydroxy group at C3 and C5 positions of the starting material cis-t - butyl-6-substituted-3,5-dihydroxy-hexanoate with trialkyl orthoformate, reducing the terminal nitro or cyano group to amine group, performing JV-alkylation by sequentially reacting with ethyl 4-fluorobenzene-2-haloacetate and isobutyryl chloride, cyclizing with JV,3-diphenylpropynamide, and performing deprotection and hydrolysis. |
申请人 |
MEDICHEM KOREA. CO., LTD.;CHO, DONG-OCK;KWON, YOUNJA;CHA, KYEONG-HOI;KIM, YEONGSOOK;TAE, HYUN-SEOP |
发明人 |
CHO, DONG-OCK;KWON, YOUNJA;CHA, KYEONG-HOI;KIM, YEONGSOOK;TAE, HYUN-SEOP |