发明名称 |
Anti-microbial agents that interact with the complement system |
摘要 |
Anti-microbial therapeutic agents that act via a novel method to treat infection are compounds which may comprise a peptide with natural or non-natural amino acids, or a small molecule. The agent can bind to the surface of a microorganism and productively fix complement in order to cause lysis of the microorganism via the assembly of a membrane attack complex, thereby triggering removal of the microbe by phagocytosis. The agents may be fragments of TFPI e.g. from the C-terminus region.
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申请公布号 |
US2009176701(A1) |
申请公布日期 |
2009.07.09 |
申请号 |
US20060988906 |
申请日期 |
2006.07.24 |
申请人 |
SCHIRM SABINE;HARDY STEPHEN |
发明人 |
SCHIRM SABINE;HARDY STEPHEN |
分类号 |
A61K38/16;A61P37/04;C07K14/00 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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