摘要 |
<p>Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.</p> |
申请人 |
ALPHARMA PHARMACEUTICALS, LLC;LIANG, ALFRED;MATTHEWS, FRANK;BOEHM, GARTH;TANG, LIJUAN;JOHNSON, FRANK;STAUFFER, JOSEPH |
发明人 |
LIANG, ALFRED;MATTHEWS, FRANK;BOEHM, GARTH;TANG, LIJUAN;JOHNSON, FRANK;STAUFFER, JOSEPH |