EXO1 promoter polymorphism associated with exceptional life expectancy in humans

摘要

The invention relates to an exonuclease 1 ( EXO1 ) promoter polymorphism associated with exceptional life expectancy in humans. More specifically, the invention relates to the promoter region of EXO1 where the gene has been found to be mutated. Moreover, the invention relates to a gene regulation mechanism involving transcription factor E47 as a transcriptional repressor of EXO1.