RECOMBINANT MICROORGANISMS HAVING PRODUCIBILITY OF COENZYME Q10 AND METHOD FOR PREPARING COENZYME Q10 USING THE SAME

摘要

A recombinant microorganism having the productivity of coenzyme Q10 is provided to improve the productivity of coenzyme Q10 by limiting the synthesis of coenzyme Q10 which is a by-product. A recombinant microorganism having a coenzyme Q10 productivity has a gene (ddsA) which codes a decaprenyl diphosphate synthetase (DPS) of the sequence number 1[SEQ ID NO:1]. The decaprenyl diphosphate synthetase (DPS) is an amino acid of the sequence number 2. The gene (ddsA) is derived from glucobacter oxidans 621H. The microorganism is Escherichia coli. The coenzyme Q10 is produced by culturing the recombinant microorganism and collect the coenzyme Q10 from cultured microorganism. The gene (mddsA) is mutated in a gene of the sequence number 1 coding a glucobacter oxidans 621H derived decaprenyl diphosphate synthase.