发明名称 |
RECOMBINANT POXVIRUS FOR CHIMERIC PROTEINS OF THE HUMAN IMMUNODEFICIENCY VIRUS |
摘要 |
The invention relates to HIV chimeric gene formed by the union of fragments of different genes of said virus, wherein said fragments contains epitopes for cytotoxic T cells (CTL) or HIV-1 auxiliary T cells, which are presented by a wide range of antigens of type Major Histocompatibility Complex (HLA-I). Recombinant poxviruses are obtained from said genes, which are useful for prophylactic and therapeutic vaccination against HIV/AIDS infections, are capable of generating a protective immune cell response in vaccinated laboratory animals and are recognized by the CTL lymphocytes of HIV/AIDS patients. |
申请公布号 |
EP1371730(B1) |
申请公布日期 |
2009.07.08 |
申请号 |
EP20020703488 |
申请日期 |
2002.02.22 |
申请人 |
CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CIGB) |
发明人 |
IGLESIAS PEREZ, ENRIQUE;VAZQUEZ BLOMQUIST, DANIA, M.;DUARTE CANO, CARLOS, A. |
分类号 |
C12N15/09;C12N15/48;A61K35/76;A61K38/00;A61K39/21;A61K39/275;A61K45/00;A61K48/00;A61P31/12;A61P31/18;A61P37/00;A61P43/00;C07K14/065;C07K14/155;C07K14/16;C07K19/00;C12N7/00;C12N7/01;C12N15/11;C12N15/33;C12N15/39;C12N15/62;C12N15/863;C12R1/93 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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