发明名称 |
COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM |
摘要 |
The present invention provides compositions and methods for prevention and prophylaxis of neurological diseases accompanied by neuronal death. The invention includes synthesis of 5-benzylamino salicylic acid (BAS) and its derivatives. BAS and its derivatives protect cortical neurons from toxic insults by N-methyl-D-aspartate, Zn2+, and reactive oxygen species. Thus, the present invention provides compositions and methods for treating stroke, traumatic brain and spinal cord injury, epilepsy, and neurodegenerative diseases that are accompanied by severe neuronal loss via excitotoxicity, Zn2+ neurotoxicity, and free radical neurotoxicity.
|
申请公布号 |
CA2405518(C) |
申请公布日期 |
2009.07.07 |
申请号 |
CA20002405518 |
申请日期 |
2000.04.19 |
申请人 |
NEUROTECH CO., LTD. |
发明人 |
YOON, SUNG HWA;GWAG, BYOUNG JOO;RYU, BO RUM;MOON, HO SANG;LEE, YOUNG AE |
分类号 |
C07C229/64;C12M3/00;A61B;A61B17/42;A61B17/435;A61B19/02;A61D19/02;A61D19/04;A61K31/196;A61K31/606;A61K31/618;A61K31/621;A61P3/10;A61P7/06;A61P19/08;A61P21/04;A61P25/00;A61P25/08;A61P25/14;A61P25/16;A61P25/28;A61P43/00;C07C233/54;C07C233/81;C07C311/21;C12N5/06 |
主分类号 |
C07C229/64 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|