发明名称 |
Substituted pyrimidines useful as protein kinase inhibitors |
摘要 |
The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.
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申请公布号 |
US7557106(B2) |
申请公布日期 |
2009.07.07 |
申请号 |
US20060500981 |
申请日期 |
2006.08.09 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
CHARRIER JEAN-DAMIEN;MAZZEI FRANCESCA;KAY DAVID;MILLER ANDREW |
分类号 |
C07D403/14;A61K31/4155;A61K31/439;A61K31/506;A61K31/5377;A61K31/541;A61K31/551;A61P3/00;A61P5/00;A61P9/00;A61P11/06;A61P13/08;A61P19/00;A61P25/00;A61P25/28;A61P29/00;A61P35/00;A61P35/02;A61P37/06;A61P37/08;A61P43/00;C07D239/34;C07D401/14;C07D403/12;C07D453/02 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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