发明名称 |
GENETICALLY MODIFIED ATTENUATED VESICULAR STOMATITIS VIRUS, COMPOSITIONS AND METHODS OF USE THEREOF |
摘要 |
The present invention relates to methods for generating genetically modified and attenuated strains of vesicular stomatitis virus (VSV) for use in the preparation of immunogenic compositions. More particularly, the invention relates to the identification of particular genetic modifications of attenuated VSV that result in an increased yield of virus and an increase in stability of the attenuated strains for preparation of the immunogenic compositions. Methods for cell culture propagation and use in large scale production of VSV is also disclosed. |
申请公布号 |
CA2710350(A1) |
申请公布日期 |
2009.07.02 |
申请号 |
CA20082710350 |
申请日期 |
2008.12.18 |
申请人 |
WYETH LLC |
发明人 |
KAYLAN, NARENDER KUMAR;YURGELONIS, IRINA;HENDRY, ROGER MICHAEL;CUTLER, MARK;SYVERTSEN, KRISTEN ELISSA |
分类号 |
C07K14/005;A61K39/205;C12N7/08 |
主分类号 |
C07K14/005 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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