The present invention provides an influenza B virus M gene with a modification of at least one nucleotide proximate to the N-terminus of the M gene, more specifically at any one of nucleotide positions 265 to 294 of the M gene as well as an influenza B virus comprising said modified M gene. Further, its use for the preparation of a vaccine and methods for preparing said modified influenza virus are disclosed.
申请公布号
WO2009080806(A2)
申请公布日期
2009.07.02
申请号
WO2008EP68154
申请日期
2008.12.22
申请人
AVIR GREEN HILLS BIOTECHNOLOGY RESEARCH DEVELOPMENT TRADE AG;KITTEL, CHRISTIAN;WRESSNIGG, NINA