Y2 RECEPTOR AGONISTS

摘要

A polypeptide agonist of the Y2 receptor selective for the Y2 receptor over the Y1 and Y4 receptors, which is a functional mimic of the 3-36 truncated variant of the polypeptide PYYl- 36 and has the general formula (1) in which variant said PYY 1-36 sequence is modified to include a branch point (BP) at an amino acid position between position 1 and position 14 provided by a replacement or additional natural or artificial amino acid residue BP having a first amino group, a second amino acid group, which is not an a amino group, and a carboxylic acid group, the said first amino group having bonded thereto an amino acid sequence of from 0 to 15 amino acids, said second amino group being bonded to a PYY partial sequence, and said carboxylic acid group being bonded to an alpha helical amino acid sequence.