| 摘要 |
<p>This invention relates to novel palladium (Pd) and platinum (Pt) phosphine complexes. The invention further relates to their use, more particularly, but not exclusively, as anti tumour agents. According to a first aspect of the invention there is provided a complex having the general Formula (I); wherein: (i) M is a Pt or Pd metal; (ii) Formula (II) and Formula (II) are ligands wherein P is bound to M and wherein (a) A may be a (CH2)n group wherein n is 2, 3, cis CH=CH or C?C, (b) R1, R2, R3, R4, R5, R6, R7 and R8 are the same or different and may be selected from the group consisting of phenyl, substituted phenyl, 4-pyridyl, substituted 4-pyridyl, 3-pyridyl, substituted 3-pyridyl, 2-pyridyl and substituted 2-pyridyl, (iii) X may be a monovalent anion or 2X may be a divalent anion, and (iv) M's metal centre is co-ordinatingly saturated such that X is unable to bind with M The present invention also relates to the use of a complex of Formula (I) in the manufacture of a medicament for the inhibition of tumours</p> |
