RAS FUSION PROTEIN

摘要

A Ras fusion protein, which a part of N-Ras protein and a part of H-Ras protein are combined, is provided to identify interaction between Ras protein signal pathway and cancer generation and develop the molecule target cancer theraphy. A Ras fusion protein has a form which the first to nth amino acid of a N-Ras (neuroblastoma-Ras) protein and n+1th to 189th amino acid of H-Ras(Harvey-Ras) protein are combined, and n is integer under 165. The fusion protein has the combination form of 1-120th amino acid of N-Ras protein and 121-189th amino acid of H-Ras protein. The fusion protein has the combination form of 1-141th amino acid of N-Ras protein and 142-189th amino acid of H-Ras protein. The fusion protein has the combination form of 1-165th amino acid of N-Ras protein and 166-189th amino acid of the H-Ras protein. The 12th amino acid of the fusion protein is substituted with Asp for Gly.