摘要 |
The present invention provides targeting lipids of structure (C1) L100 -linker - L101, where L100 is a lipid, lipophile, alkyl, alkenyl or alkynyl, L101 is a ligand or -CH2CH2(OCH2CH2)p O(CH2)q CH2-ligand, p is 1-1000, and q is 1-20. In addition, the invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
MANOHARAN, MUTHIAH;RAJEEV, KALLANTHOTTATHIL G.;NARAYANANNAIR, JAYAPRAKASH K.;JAYARAMAN, MUTHUSAMY |