发明名称 |
NON-AGGREGATING HUMAN VH DOMAINS |
摘要 |
The present invention relates to non-aggregating VH domains or libraries thereof. The VH domains comprise at least one disulfide linkage-forming cysteine in at least one complementarity-determining region (CDR) and an acidic isoelectric point (pI). A method of increasing the power or efficiency of selection of non-aggregating VH domains comprises panning a phagemid-based VH domain phage-display library in combination with a step of selecting non-aggregating phage-VH domains. Compositions of matter comprising the non-aggregating VH domains, as well as methods of use are also provided.
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申请公布号 |
CA2708074(A1) |
申请公布日期 |
2009.07.02 |
申请号 |
CA20082708074 |
申请日期 |
2008.12.22 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
ARBABI-GHAHROUDI, MEHDI;TANHA, JAMSHID |
分类号 |
C07K16/00;A61K39/395;A61P37/04;C07K16/12;C12N15/13;C12Q1/68;C40B30/04;C40B40/02;C40B40/10;G01N33/53;G01N33/567 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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