| 摘要 |
A pharmaceutical composition for treating sepsis and septic shock is provided to suppress multiple organ dysfunction syndrome related to organ damage and lower mortality. A pharmaceutical composition for treating sepsis and septic shock comprises a compound of the chemical formula 1 or its pharmaceutically allowable salt as an active ingredient. In the chemical formula 1, R1, R2, and R3 are hydrogen, or residue of the chemical formula 2. In the chemical formula 1, R4 is hydrogen, alkyl group of 1-6 carbon atoms. The compound of the chemical formula 1 is chlorogenic acid, and comprises 3-caffeoylquinic acid, 4-caffeoylquinic acid, 5-caffeoylquinic acid, 3,4-caffeoylquinic acid, 3,5-caffeoylquinic acid, or 4,5-dicaffeoylquinic acid. The pharmaceutical composition suppresses organic damage by the sepsis. The organ is liver, kidney, or heart. The pharmaceutical composition further comprises carrier, excipient, or diluents.
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