| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a new 1-aza-bicycloalkyl derivative. <P>SOLUTION: There are provided 1-aza-bicycloalkyl derivatives which areα7-nicotinic acetylcholine receptor (nAChR) agonists, represented by formula (I) [wherein X is CH<SB>2</SB>or a single bond; Y is a group of formula (A); R is a substituted or unsubstituted 5-10C aryl or (un)substituted hetero-5-10C aryl, N(R<SP>1</SP>)(R<SP>4</SP>) or N(R<SP>2</SP>)(CHR<SP>3</SP>R<SP>4</SP>) (wherein R<SP>1</SP>, R<SP>2</SP>and R<SP>3</SP>are each independently H, 1-4C alkyl or CF<SB>3</SB>; and R<SP>4</SP>is a substituted or unsubstituted 5-10C aryl or (un)substituted hetero-5-10C aryl)]. The method for production of these derivatives, their use as pharmaceuticals and pharmaceutical compositions comprising them are also disclosed. <P>COPYRIGHT: (C)2009,JPO&INPIT</p> |
