| 摘要 |
The invention relates to a tobacco alkaloid patch for transdermal administration of a tobacco alkaloid, said patch comprising an impermeable backing (17) and a membrane (14) which defines a reservoir (12) there between, said membrane (14) being permeable to and in contact with said tobacco alkaloid, said impermeable backing (17) and said membrane (14) being at least partly joined by a sealing (11), wherein said patch has a flexural strength of less than about 250 mN/mm. According to an advantageous embodiment of the invention, very high-dose nicotine patches may be obtained having acceptable membrane areas and featuring acceptable user comfort.
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