发明名称 |
EFFICIENT ASPIRIN PRODRUGS |
摘要 |
Aspirin is one of the most widely used drugs in the treatment of inflammation, pain and fever. It has more recently found application in the prevention of heart attacks and stroke and is being studied as a cancer chemopreventative agent. Despite its value aspirin continues to be underutilized because it causes gastric bleeding. The technology under development potentially removes this problem. It is designed to reduce contact between the drug and the intestinal lining. An isosorbide aspirinate prodrug compound is thus provided. The compound has the general structure as shown in general formula (I) wherein Y is a C1 - C8 alkyl ester, a C1 - C8 alkoxy ester, a C3 - C10 cycloalkyl ester, an arylester, a C1 - C8 alkylaryl ester or -C(O)ORring, wherein Rring is a 5-membered aromatic or nonaromatic 5-member ring having at least one heteroatom substituted for a carbon of the ring system, which can be unsubstituted or substituted with at least one nitric oxide releasing group.
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申请公布号 |
CA2709432(A1) |
申请公布日期 |
2009.07.02 |
申请号 |
CA20082709432 |
申请日期 |
2008.12.19 |
申请人 |
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVID ED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN |
发明人 |
GILMER, JOHN FRANCIS;CLUNE-MORIARTY, LOUISE;LALLY, MAEVE |
分类号 |
C07D493/04;A61K31/34;A61P29/00 |
主分类号 |
C07D493/04 |
代理机构 |
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