发明名称 |
THREE-DIMENSIONAL STRUCTURE OF FabK PROTEIN AND METHOD OF DEVELOPING A FabK PROTEIN INHIBITOR USING THE SAME |
摘要 |
The present invention relates to a FabK (enoyl-acyl carrier protein reductase) protein derived from a Thermotoga maritima strain. In the present invention, the active site and the three-dimensional crystal structure of the protein are determined, a novel inhibitor against the FabK protein is screened and/or designed using the three-dimensional crystal structure thereof, and thereby developing a novel active compound, namely active-controlling material with excellent antibiotic activities against strains having a resistance to previous antibiotics.
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申请公布号 |
US2009170117(A1) |
申请公布日期 |
2009.07.02 |
申请号 |
US20070965989 |
申请日期 |
2007.12.28 |
申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
KIM EUNICE EUN-KYEONG;HA BYUNG-HAK |
分类号 |
G01N33/53;C12N9/02;G06F17/50 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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