摘要 |
<p>The present application discloses oxadiazole based compounds of Formula (I) active on sphingosine-1-phosphate (S1P) in particular useful to treat lupus erythematosus. A is phenyl or a 5 or 6-membered heteroaryl ring; R1 is up to two substituents independently selected from halogen, C(1-3)aIkoxy, C(1-3)flyoroalkyl, cyano, optionally substituted phenyl. C(1-3)fluoroalkoxy. C(1-6)alkyl and C(3-6)Cyctoalkyl; R2 is hydrogen, halogen or C(1-4)alkyl; B is a 7 membered saturated ring selected from the following: Formulae (a) (b) (c) R3 is hydrogen or (CH2)1-4MCO2H; R4 is hydrogen or C(1-3)alkyl optionally interrupted by oxygen;</p> |
申请人 |
GLAXO GROUP LIMITED;DEMONT, EMMANUEL, HUBERT;HEER, JAG, PAUL;HEIGHTMAN, THOMAS, DANIEL;HURST, DAVID, NIGEL;JOHNSON, CHRISTOPHER, NORBERT;SKIDMORE, JOHN;WALL, IAN, DAVID;WITHERINGTON, JASON |
发明人 |
DEMONT, EMMANUEL, HUBERT;HEER, JAG, PAUL;HEIGHTMAN, THOMAS, DANIEL;HURST, DAVID, NIGEL;JOHNSON, CHRISTOPHER, NORBERT;SKIDMORE, JOHN;WALL, IAN, DAVID;WITHERINGTON, JASON |