发明名称 |
PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY |
摘要 |
<p>Disclosed are: a compound represented by the general formula (I), (II) or (III), or a pharmacologically acceptable salt, solvate or hydrate thereof; and a pharmaceutical composition comprising the compound or the pharmacologically acceptable salt, solvate or hydrate thereof as an active ingredient. The compound has an excellent ACAT2-inhibiting activity, and the mechanism of action of the compound is different from that of a statin-containing pharmaceutical agent. Therefore, the compound can be used as a therapeutic or prophylactic agent for obesity; adiposis; hyperlipemia; hypercholesterolemia; metabolic dyslipidemia; arteriosclerosis; hyperlipemia, hypercholesterolemia, metabolic dyslipidemia, arteriosclerosis or hypertension induced by obesity; or the like.</p> |
申请公布号 |
WO2009081957(A1) |
申请公布日期 |
2009.07.02 |
申请号 |
WO2008JP73501 |
申请日期 |
2008.12.17 |
申请人 |
THE KITASATO INSTITUTE;TOMODA, HIROSHI;NAGAMITSU, TOHRU;OMURA, SATOSHI;LAWRENCE, LEE RUDEL |
发明人 |
TOMODA, HIROSHI;NAGAMITSU, TOHRU;OMURA, SATOSHI;LAWRENCE, LEE RUDEL |
分类号 |
C07D493/04;A61K31/4433;A61K31/695;A61P9/10;A61P43/00;C07D493/14;C07F7/18 |
主分类号 |
C07D493/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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